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Volume - 79, Issue - 2

editorial
Page 123
Editorial
Pages 124 - 127
Review
Pages 128 - 129
Original Papers
Pages 130 - 133
Original Papers
Pages 134 - 153
  • The effect of corticosteroid usage on the bacterial killing, clearance and nerve damage in leprosy: A prospective cohort study: Part 1 – Study design and baseline findings of 400 untreated multibacillary patients

    • Fatema Abbas Khambati
    • Vanaja Prabhakar Shetty
    • Sunil Dattatraya Ghate
    • Gospi Dolly Capadia
    • Vivek Vasudev Pai
    • Ramaswamy Ganapati
    Volume 79, Issue 2

    | Published on June 2008

    Objective

    To investigate possible adverse effects of therapeutic usage of corticosteroids on the killing and clearance of M. leprae and the clearance of granuloma, in patients with multibacillary (MB) leprosy.

    Design

    A cohort of 400 untreated MB patients were sub-grouped into those to be treated with corticosteroids (prednisolone 40 mg daily tapered to 5 mg over 12 weeks) along with MB-MDT for reaction and/or neuritis or silent neuropathy (SN) of <6 months duration (group A), and those with no reaction and to be treated with MDT only (group B). Clinical, bacteriological, histopathological and neurological test findings at fixed time points were compared. Analysis was performed using SPSS version 10.0. The significance of association was tested using Chi-square test.

    In the current report, we describe the study design and baseline findings of 400 untreated MB patients, with special emphasis on differences between patients in groups A and B.

    Results

    At baseline, applying Ridley-Jopling classification, 39% patients were BT, 20% BB, 24% BL, 12% sub-polar LL and 5% pure neural (PN). Overall, 60% patients were slit skin smear (SSS) negative and 33% presented with disability either grades 1 or 2. Overall 140/400 (35%) patients presented with reaction and/or neuritis and 11/400 (3%) presented with SN of <6 months duration.

    Comparing groups A and B, the percentage of patients presenting with DG2 was significantly higher in group A (43%). By clinical tests, monofilaments (MF) and voluntary muscle testing (VMT), the percentage of patients and nerves showing functional impairment was also significantly higher in group A. However, in the more sensitive nerve conduction velocity (NCV) test, the percentage of patients that showed nerve abnormalities was closely comparable; 94% and 91% in groups A and B respectively while number of affected nerves was higher in group A.

    Conclusion

    At baseline, as recorded by NCV, peripheral nerve function abnormality was observed in almost all the MB patients regardless of reaction; but among those presenting with reaction or neuritis, the nerve damage was more severe and extensive.

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