Pages 314 - 321 Volume 87, Issue 3
Back
0
Download
A
Results of eight years follow up among multibacillary patients treated with Uniform Multidrug Therapy in China
Yan Liangbin
  Yan Liangbin
Affiliation
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
 Find this author on Google Scholar
 Find this author on PubMed
a
Shen Jianping
  Shen Jianping
Affiliation
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
 Find this author on Google Scholar
 Find this author on PubMed
a
Yu Meiwen
  Yu Meiwen
Affiliation
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
 Find this author on Google Scholar
 Find this author on PubMed
a
Zhang Guocheng
  Zhang Guocheng
Affiliation
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
 Find this author on Google Scholar
 Find this author on PubMed
a
Li Jinlan
  Li Jinlan
Affiliation
Guizhou Provincial Center for Disease Control and Prevention
 Find this author on Google Scholar
 Find this author on PubMed
b
Yu Xiufeng
  Yu Xiufeng
Affiliation
Wenshan Institute of Dermatology, Yunnan Province
Correspondence to: Shen Jianping, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China (e-mail: shenjp@ncstdlc.org)
 Find this author on Google Scholar
 Find this author on PubMed
c,*
Objective:

To analyse the results of treatment among multibacillary (MB) patients 8 years after treatment with 6 months multidrug therapy (MDT). Methods: Newly detected and relapsed MB leprosy patients were treated with 6 months WHO-MDT. The patients were followed up for 8 years. The effectiveness of treatment was assessed by clinical status and bacteriological changes.

 Results:

A total of 114 patients were recruited. Forty two patients dropped out from the study for various reasons. Only 72 patients remained for the final analysis. The mean Bacteriological Index (BI) of all patients decreased from 2.93 ± 1.39 before treatment, to 0 at the end of the eight year follow up period, with an average annual BI decrease of 0.42. The rate of smear negativity of all patients was 100% at the end of follow up. 38 (53%) patients experienced leprosy reactions during the study and one patient relapsed, giving a cumulative relapse rate of 1.3% or 0.035 per 100 patient-years.

 Conclusion:

The finding that all MB cases with initially positive skin smears, who were treated with only 6 months of MB-MDT, became negative within 8 years showed that the response to this regimen is good in a majority of MB cases.
Cite this article
Yan Liangbin, Shen Jianping, Yu Meiwen, Zhang Guocheng, Li Jinlan, Yu Xiufeng;
Results of eight years follow up among multibacillary patients treated with Uniform Multidrug Therapy in China; Leprosy Review; 2016; 87; 3; 314-321; DOI: 10.47276/lr.87.3.314
home.article_information

DOI: 10.47276/lr.87.3.314

articleview.journal_title: Leprosy Review
articleview.publisher: British Leprosy Relief Association
articleview.publisher_location: Colchester, UK
articleview.article_date_pre accepted on 21 June 2016 and articleview.pub_on 01 September 2016
© Lepra 2016
LEPROSY
Leprosy Review
0305-7518
British Leprosy Relief Association
Colchester, UK
31-4321
0305-7518/16/064053+08
10.47276/lr.87.3.314
Original Papers
Results of eight years follow up among multibacillary patients treated with Uniform Multidrug Therapy in China
Y. Liangbin et al.
Eight years’ study among MB patients with UMDT
LiangbinYan
a
JianpingShen
a
MeiwenYu
a
GuochengZhang
a
JinlanLi
b
XiufengYu
c
a
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
b
Guizhou Provincial Center for Disease Control and Prevention
c
Wenshan Institute of Dermatology, Yunnan Province
Correspondence to: Shen Jianping, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China (e-mail: )
01092016
87
3
314
321
21062016
© Lepra
2016
Objective:
To analyse the results of treatment among multibacillary (MB) patients 8 years after treatment with 6 months multidrug therapy (MDT). Methods: Newly detected and relapsed MB leprosy patients were treated with 6 months WHO-MDT. The patients were followed up for 8 years. The effectiveness of treatment was assessed by clinical status and bacteriological changes.
Results:
A total of 114 patients were recruited. Forty two patients dropped out from the study for various reasons. Only 72 patients remained for the final analysis. The mean Bacteriological Index (BI) of all patients decreased from 2.93 ± 1.39 before treatment, to 0 at the end of the eight year follow up period, with an average annual BI decrease of 0.42. The rate of smear negativity of all patients was 100% at the end of follow up. 38 (53%) patients experienced leprosy reactions during the study and one patient relapsed, giving a cumulative relapse rate of 1.3% or 0.035 per 100 patient-years.
Conclusion:
The finding that all MB cases with initially positive skin smears, who were treated with only 6 months of MB-MDT, became negative within 8 years showed that the response to this regimen is good in a majority of MB cases.
leprosyuniform multidrug therapybacteriological indexleprosy reactio