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Results from the Clinical Trial of Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR): Decrease in Bacteriological Index
Maria Lucia Fernandes Penna
  Maria Lucia Fernandes Penna
Affiliation
Epidemiology and Biostatistics Department, Universidade Federal Fluminense, Rio de Janeiro, Brazil
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a
Samira Bűhrer-sékula
  Samira Bűhrer-sékula
Affiliation
Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Goias, Brazil
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b
Maria Araci De Andrade Pontes
  Maria Araci De Andrade Pontes
Affiliation
Dona Libânia Dermatology Centre, Fortaleza, Ceará, Brazil
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c
Rossilene Cruz
  Rossilene Cruz
Affiliation
Tropical Dermatology and Venerology Alfredo da Matta Foundation, Manaus, Amazonas, Brazil
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d
Heitor De Sá Gonçalves
  Heitor De Sá Gonçalves
Affiliation
Dona Libânia Dermatology Centre, Fortaleza, Ceará, Brazil
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c
Gerson Oliveira Penna
  Gerson Oliveira Penna
Affiliation
Tropical Medicine Centre, University of Brasília, Brasília DF, Brazil
Correspondence to: Gerson Oliveira Penna, Núcleo de Medicina Tropical, Universidade de Brasília. Campus Universitário Darcy Ribeiro – Caixa Postal 4517 – Asa Norte- Brasília – DF, CEP 70.904-970, Brazil (e-mail: gpenna@gpenna.net)
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e,*
Background:

Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control.

 Objective:

To evaluate the association between treatment duration and the trend in bacteriological index (BI) decrease over time among patients given Uniform MDT (UMDT) compared to those given regular MDT (RMDT).

 Methods:

An open-label randomised clinical trial to compare the present routine treatment with one lasting six month. Patient intake was from March 2007 to February 2012. To evaluate the trend of BI as a function of time, a multilevel linear with mixed effects model was fixed to the two study groups and also four groups after stratification by BI, less than 3 and 3 or more.

 Results:

The BI fall was higher among those taking RMDT, this difference however was not statistically significant.

 Conclusion:

The results presented here support the possibility of use of UMDT in the field, but further follow up is still needed for a final conclusion.
Cite this article
Maria Lucia Fernandes Penna, Samira Bűhrer-sékula, Maria Araci De Andrade Pontes, Rossilene Cruz, Heitor De Sá Gonçalves, Gerson Oliveira Penna;
Results from the Clinical Trial of Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR): Decrease in Bacteriological Index; Leprosy Review; 2014; 85; 4; 262-266; DOI: 10.47276/lr.85.4.262
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DOI: 10.47276/lr.85.4.262

articleview.journal_title: Leprosy Review
articleview.publisher: British Leprosy Relief Association
articleview.publisher_location: Colchester, UK
articleview.article_date_pre accepted on 14 October 2014 and articleview.pub_on 01 December 2014
© Lepra 2014
LEPROSY
Leprosy Review
0305-7518
British Leprosy Relief Association
Colchester, UK
26-2266
0305-7518/14/064053+05
10.47276/lr.85.4.262
Original Papers
Results from the Clinical Trial of Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR): Decrease in Bacteriological Index
PennaMaria Lucia Fernandes
a
Bűhrer-sékulaSamira
b
PontesMaria Araci De Andrade
c
CruzRossilene
d
GonçalvesHeitor De Sá
c
PennaGerson Oliveira
e
a
Epidemiology and Biostatistics Department, Universidade Federal Fluminense, Rio de Janeiro, Brazil
b
Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Goias, Brazil
c
Dona Libânia Dermatology Centre, Fortaleza, Ceará, Brazil
d
Tropical Dermatology and Venerology Alfredo da Matta Foundation, Manaus, Amazonas, Brazil
e
Tropical Medicine Centre, University of Brasília, Brasília DF, Brazil
Correspondence to: Gerson Oliveira Penna, Núcleo de Medicina Tropical, Universidade de Brasília. Campus Universitário Darcy Ribeiro – Caixa Postal 4517 – Asa Norte- Brasília – DF, CEP 70.904-970, Brazil (e-mail: )
01122014
85
4
262
266
14102014
© Lepra
2014
Background:
Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control.
Objective:
To evaluate the association between treatment duration and the trend in bacteriological index (BI) decrease over time among patients given Uniform MDT (UMDT) compared to those given regular MDT (RMDT).
Methods:
An open-label randomised clinical trial to compare the present routine treatment with one lasting six month. Patient intake was from March 2007 to February 2012. To evaluate the trend of BI as a function of time, a multilevel linear with mixed effects model was fixed to the two study groups and also four groups after stratification by BI, less than 3 and 3 or more.
Results:
The BI fall was higher among those taking RMDT, this difference however was not statistically significant.
Conclusion:
The results presented here support the possibility of use of UMDT in the field, but further follow up is still needed for a final conclusion.