British Leprosy Relief Association
Primary results of Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR): reactions frequency in multibacillary patients
M. L. F. Penna et al.
U-MDT Leprosy clinical trial Brazil
Fernandes PennaMaria Luciad
Andrade pontesMaria araci deb
GonçalvesHeitor de sáb
aTropical Medicine Centre, University of Brasília, Brasília DF, Brazil
bDona Libânia Dermatology Centre, Fortaleza, Ceará, Brazil
cTropical Dermatology and Venerology Alfredo da Matta Foundation, Manaus, Amazonas, Brazil
dEpidemiology and Biostatistics Department, Universidade Federal Fluminense, Rio de Janeiro, Brazil
eTropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Goias, Brazil
Correspondence to: Gerson Oliveira Penna, Núcleo de Medicina Tropical, Universidade de Brasília. Campus Universitário Darcy Ribeiro - Caixa Postal 4517 - Asa Norte - Brasília - DF, CEP 70.904-970 (e-mail: firstname.lastname@example.org)
Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment, allowing for uniform treatment for all cases, makes case classification superfluous and therefore simplifies leprosy control.
To evaluate the association of the treatment duration with the frequency of reactions among MB patients.
An open-label randomised clinical trial to compare the present routine treatment with one lasting six months. Patients were recruited between March 2007 and February 2012. We analysed the frequency of first reaction with the Kaplan-Meier method and of recurrent reaction with a Poisson regression, using the treatment group and baciloscopic index level (BI) as independent variables. Logistic regression was used to evaluate the statistical association of different reaction types and the treatment group.
Among those with BI < 3, we found a statistical significant difference of reaction frequencies between the treatment groups from 6 to 18 months since the beginning of treatment. This difference disappears at 2 years after the start of treatment. Multiple reactions were associated with the treatment group and with BI ≥ 3. No specific types of reactions were associated with treatment duration.
Although this is the first report of U-MDT/CT-BR, the results presented here support the possibility of use of UMDT in the field.