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Adverse effects of Multi-drug therapy in leprosy, a two years’ experience (2006–2008) in tertiary health care centre in the tribal region of Chhattisgarh state (Bastar, Jagdalpur)
Harminder Singh
  Harminder Singh
Affiliation
Assistant Professor, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India
Correspondence to: Harminder Singh, Assistant Professor, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India (Tel: 09406006350; e-mail: dr˙harminderchahal@rediffmail.com)
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a,*
Bithika Nel
  Bithika Nel
Affiliation
Demonstrator, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India
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b
Vivek Dey
  Vivek Dey
Affiliation
Assistant Professor, Department of Dermatology, Govt. Medical College, Jagdalpur (C.G), India
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c
Pawan Tiwari
  Pawan Tiwari
Affiliation
Demonstrator, Department of Anatomy, Govt. Medical College, Jagdalpur (C.G), India
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d
Naveen Dulhani
  Naveen Dulhani
Affiliation
Assistant Professor, Department of Medicine, Govt. Medical College, Jagdalpur (C.G), India
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e
Objective:

To assess the adverse effects of multi drug therapy (MDT) in leprosy patients.

 Methods:

A prospective and descriptive study carried out in Department of Dermatology, Government Medical College, Jagdalpur. The adverse effects were recorded on the personal record of every individual patient, filled during the course of treatment.

 Results:

176 patient’s records were analysed, looking for adverse effects. Among the 176 patients, 79 had adverse effects due to one or more components of MDT, 73 had adverse effects due to dapsone, eight due to rifampicin and 16 due to clofazimine. Mean (+ ∕−SD) duration for the development of adverse effects from the start of therapy was 1.99 (+ ∕−0.69) months for dapsone, 3.6 (+ ∕−0.68) months for rifampicin and 7.13 (+ ∕−0.79) months for clofazimine. There was a significant (P < 0.05) correlation between adverse effects and low Body Mass Index (BMI). The suspected drug was stopped and an alternative regime started in nine patients; six had dapsone stopped, two had rifampicin stopped and one had clofazimine stopped.

 Conclusion:

Adverse effects attributed to MDT are comparable to previous studies and we found that ADR due to Dapsone was very high but most of the ADR were managed by supportive treatment without replacing the suspected drug.
Cite this article
Harminder Singh, Bithika Nel, Vivek Dey, Pawan Tiwari, Naveen Dulhani;
Adverse effects of Multi-drug therapy in leprosy, a two years’ experience (2006–2008) in tertiary health care centre in the tribal region of Chhattisgarh state (Bastar, Jagdalpur); Leprosy Review; 2011; 82; 1; 17-24; DOI: 10.47276/lr.82.1.17
home.article_information

DOI: 10.47276/lr.82.1.17

articleview.journal_title: Leprosy Review
articleview.publisher: British Leprosy Relief Association
articleview.publisher_location: Colchester, UK
articleview.article_date_pre accepted on 09 September 2010 and articleview.pub_on 01 March 2011
© Lepra 2011
LEPROSY
Leprosy Review
0305-7518
British Leprosy Relief Association
Colchester, UK
01-7024
0305-7518/11/064053+08
10.47276/lr.82.1.17
Original Papers
Adverse effects of Multi-drug therapy in leprosy, a two years’ experience (2006–2008) in tertiary health care centre in the tribal region of Chhattisgarh state (Bastar, Jagdalpur)
SinghHarminder
a
NelBithika
b
DeyVivek
c
TiwariPawan
d
DulhaniNaveen
e
a
Assistant Professor, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India
b
Demonstrator, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India
c
Assistant Professor, Department of Dermatology, Govt. Medical College, Jagdalpur (C.G), India
d
Demonstrator, Department of Anatomy, Govt. Medical College, Jagdalpur (C.G), India
e
Assistant Professor, Department of Medicine, Govt. Medical College, Jagdalpur (C.G), India
Correspondence to: Harminder Singh, Assistant Professor, Department of Pharmacology, Govt. Medical College, Jagdalpur (C.G), India (Tel: 09406006350; e-mail: )
01032011
82
1
17
24
09092010
© Lepra
2011
Objective:
To assess the adverse effects of multi drug therapy (MDT) in leprosy patients.
Methods:
A prospective and descriptive study carried out in Department of Dermatology, Government Medical College, Jagdalpur. The adverse effects were recorded on the personal record of every individual patient, filled during the course of treatment.
Results:
176 patient’s records were analysed, looking for adverse effects. Among the 176 patients, 79 had adverse effects due to one or more components of MDT, 73 had adverse effects due to dapsone, eight due to rifampicin and 16 due to clofazimine. Mean (+ ∕−SD) duration for the development of adverse effects from the start of therapy was 1.99 (+ ∕−0.69) months for dapsone, 3.6 (+ ∕−0.68) months for rifampicin and 7.13 (+ ∕−0.79) months for clofazimine. There was a significant (P < 0.05) correlation between adverse effects and low Body Mass Index (BMI). The suspected drug was stopped and an alternative regime started in nine patients; six had dapsone stopped, two had rifampicin stopped and one had clofazimine stopped.
Conclusion:
Adverse effects attributed to MDT are comparable to previous studies and we found that ADR due to Dapsone was very high but most of the ADR were managed by supportive treatment without replacing the suspected drug.