Pages 27 - 33 Volume 81, Issue 1
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The efficacy of a four-week, ofloxacin-containing regimen compared with standard WHO-MDT in PB leprosy
Objectives:

To compare the efficacy of a 4-week ofloxacin-containing regimen and the standard WHO-MDT regimen for PB leprosy, in terms of the rate and timing of relapse after treatment completion.

Design:

124 PB patients were enrolled in a randomised, double-blind trial. Of these, 66 received the standard 6-month WHO-MDT regimen, whereas 58 received 28 daily supervised doses of rifampicin 600 mg + ofloxacin 400 mg, plus 5 months of placebo. Patients were regularly monitored for clinical response and for signs of relapse after treatment completion.

Results:

Patients enrolled in the ofloxacin group had a mean follow-up of 10.8 years (628 patient-years) with 1 early relapse at 3 years after treatment completion. On relapse, this patient remained smear negative but was reclassified by current WHO criteria (≥6 skin lesions) as multibacillary (MB). Patients on the WHO-MDT regimen had a mean follow-up of 11.3 years (749 patient-years) with two late relapses at 8 and 12 years, both still classified as PB on relapse.

Conclusion:

In conclusion, both regimens appeared generally efficacious, and, in particular, resulted in few relapses.

Cite this article
Marivic F. Balagon, Roland V. Cellona, Rodolfo M. Abalos, Robert H. Gelber, Paul R. Saunderson;
The efficacy of a four-week, ofloxacin-containing regimen compared with standard WHO-MDT in PB leprosy; Leprosy Review; 2010; 81; 1; 27-33; DOI: 10.47276/lr.81.1.27
LEPROSY
Leprosy Review
0305-7518
British Leprosy Relief Association
Colchester, UK