Pages 141 - 147 Volume 74, Issue 2
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Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity

The World Health Organization (WHO) Field Trials of multidrug therapy (MDT) started at Schieffelin Leprosy Research and Training Centre (SLR & IC), Karigiri, India in December 1981. The patients were treated with two MDT regimens. The first (regimen A) consisted of 600 mg rifampicin and 300 mg of clofazimine given under supervision on 2 consecutive days monthly, 225 mg injection of acedapsone bimonthly and dapsone 100 mg daily. The second regimen (regimen B) was the conventional MDT (WHO/MDT), rifampicin 600 mg and clofazimine 300 mg supervised once a month, dapsone 100 mg and clofazimine 50 mg daily, unsupervised. Both the regimens were administered for a minimum period of 2 years or until skin smear negativity, whichever occurred later. Thirty-four newly detected previously untreated MB patients, 16 of whom received regimen A and 18 regimen B, were reassessed. Both regimens were well accepted and well tolerated by the patients. Clofazimine discolouration was the only adverse effect of MDT seen in these patients. After completion of treatment with MDT, the patients were followed up for a total duration of 466 person-years with a mean of 13. 7 ± 1. 4 years per patient. No relapse was seen.

Cite this article
Isaac Neeraj Shaw, M. Christian, K. Jesudasan, Nisha Kurian, Geetha S. Rao;
Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity; Leprosy Review; 2003; 74; 2; 141-147; DOI: 10.47276/lr.74.2.141
LEPROSY
Leprosy Review
0305-7518
British Leprosy Relief Association
Colchester, UK